Genomics

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Discovery of TAF1's role could revolutionize cancer treatment

A new study led by Stephen D. Nimer, M.D., director of Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine, shows how a key molecule regulates the generation of new blood cells, a process called hematopoiesis that goes awry in cancer. The findings have the potential to lead to new therapeutic strategies targeting the molecule, a regulator of gene activity called TAF1.

26 Jul 2025

Reactivating silent genes offers hope for Rett syndrome treatment

Researchers led by UC Davis Health scientist Sanchita Bhatnagar have developed a promising gene therapy that could treat Rett syndrome.

23 Jul 2025

New method genetically blocks mosquitoes from transmitting malaria

Mosquitoes kill more people each year than any other animal. In 2023, the blood-sucking insects infected a reported 263 million people with malaria, leading to nearly 600,000 deaths, 80% of which were children.

23 Jul 2025

Toti-N-Seq breakthrough enables universal and scalable single-cell profiling

The rapid advancement of single-cell and single-nucleus RNA sequencing (sc/snRNA-seq) has opened unprecedented windows into cellular diversity, yet existing methods for multiplexing samples struggle with scalability and accuracy.

22 Jul 2025

Prime editing reverses symptoms of severe childhood neurological disease

Scientists use a precise form of gene editing called prime editing to correct the most common genetic mutations that cause alternating hemiplegia of childhood, a rare and severe neurological disorder that begins in infancy.

21 Jul 2025

New study identifies genes that shape human brain features

What makes the human brain distinctive? A new study published July 21 in Cell identifies two genes linked to human brain features and provides a road map to discover many more.

21 Jul 2025

Ancient viral DNA found to regulate human gene expression

A new international study suggests that ancient viral DNA embedded in our genome, which were long dismissed as genetic "junk", may actually play powerful roles in regulating gene expression.

18 Jul 2025

Human eggs use a minimalist strategy to stay healthy for decades

Human eggs are some of the most patient cells in the body, lying dormant for decades until needed. A study published today in The EMBO Journal shows that the cells deliberately slow the activity of their internal waste disposal systems as they mature, most likely an evolutionary design which keeps metabolism low and damage at bay.

18 Jul 2025

CRISPR-mediated DNA methylation editing regulates inflammation and tumor growth

Genes, fragments of DNA located on our chromosomes, control much of what happens in cells.

17 Jul 2025

OmicsTweezer offers breakthrough in analyzing tumor microenvironments

Researchers have developed a powerful new tool that makes it easier to study the mix of cell types in human tissue, which is crucial for understanding diseases such as cancer.

17 Jul 2025

Unlocking bacterial genomes to develop tailored probiotic therapies

Probiotics are emerging tools used by neonatal intensive care units to promote healthy outcomes and prevent intestinal diseases such as necrotizing enterocolitis.

16 Jul 2025

Interbreeding with Neanderthals may explain risk for fatal neurological condition in modern humans

A new Simon Fraser University-led study reveals interbreeding between humans and their ancient cousins, Neanderthals, as the likely origin of a neurological condition estimated to impact up to one per cent of people today.

16 Jul 2025

Van Andel Institute scientists develop improved technique to profile DNA methylation in single cells

Van Andel Institute scientists have developed an improved technique to comprehensively profile DNA methylation in single cells, an advance that will help researchers better study the role of epigenetics in cancer and other diseases.

16 Jul 2025

Extracellular vesicle RNA reveals clues about obesity and metabolic disease

Our study examines how RNA in extracellular vesicles (EVs) can provide insights into metabolic phenotypes related to obesity. By using functional genomics approaches, we found a high representation of genes and regulatory elements previously associated with obesity and type 2 diabetes represented by the RNA cargo within these EVs.

15 Jul 2025