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Unlocking the power of stereochemistry to improve mRNA drug delivery

A team from the Max-Planck-Institut für Kohlenforschung, Hokkaido University, and Osaka University has discovered that subtle differences in molecular structure can have a major impact on the performance of mRNA-based drugs.

1 Aug 2025

Researchers trace metabolic superpowers of hibernators to shared DNA

Animals that hibernate are incredibly resilient. They can spend months without food or water, muscles refusing to atrophy, body temperature dropping to near freezing as their metabolism and brain activity slow to a crawl.

1 Aug 2025

Characterization of antibodies targeting ASO modifications for intracellular trafficking

A new article in the peer-reviewed journal Nucleic Acid Therapeutics describes the characterization of antibodies targeting antisense oligonucleotide (ASO) phosphorothioate and 2'-methoxyehtyl modifications for intracellular trafficking and biodistribution studies.

1 Aug 2025

Salk Institute's ShortStop revolutionizes genetic search

Proteins sustain life as we know it, serving many important structural and functional roles throughout the body. But these large molecules have cast a long shadow over a smaller subclass of proteins called microproteins.

1 Aug 2025

Researchers uncover PSAT1 gene as key to heart repair post-heart attack

Heart attacks remain a leading cause of death and disability worldwide. The permanent loss of heart muscle cells-known as cardiomyocytes-and the heart's limited regenerative capacity often led to chronic heart failure.

1 Aug 2025

Study sheds light on molecular mechanisms of brain aging

Aging and neurodegeneration are both known to disrupt the production of functional proteins in cells – a process called "proteostasis," or protein homeostasis.

31 Jul 2025

Cancer cells use energy surge to survive physical squeezing

Cancer cells mount an instant, energy‑rich response to being physically squeezed, according to a study published in the journal Nature Communications.

31 Jul 2025

Promega Plasmid Collection, available through Addgene, equips industry and academic researchers with powerful bioluminescent assays that provide deeper insights into endogenous cellular biology

Addgene, a purpose-driven organization helping scientists conduct experiments with greater ease, speed, and reproducibility, today announced a strategic partnership with Promega to expand Addgene’s vast plasmid repository with the launch of the Promega Plasmid Collection.

From Promega Corporation 31 Jul 2025

CPADS enables comprehensive analysis of drug resistance across 44 cancer types

CPADS integrates data from the Gene Expression Omnibus (GEO), The Cancer Genome Atlas (TCGA), and the Genomics of Drug Sensitivity in Cancer (GDSC) databases, encompassing over 29,000 samples across 44 cancer types and involving 288 drugs. It provides five main analysis modules: differential expression analysis, correlation analysis, pathway analysis, drug analysis, and gene perturbation analysis.

30 Jul 2025

New strategy reveals how mannose receptor helps regulate blood proteins

The amount of each of the more than a thousand different glycoproteins in your blood varies widely with the 10 most abundant glycoproteins accounting for 90 percent of the total mass.

30 Jul 2025

Bacteria use amyloids as molecular armor against predators

Amyloids are perhaps best known as a key driver of Alzheimer's disease.

30 Jul 2025

Innovative nanopore system enables controlled DNA unzipping

DNA holds the instructions that make us who we are. If we want to read those instructions, say to understand our predisposition to genetic disorders, we need to carefully 'unzip' DNA's iconic double-helix structure.

30 Jul 2025

New method uses exosome stiffness for lung cancer gene detection

The research team led by Senior Researchers Yoonhee Lee from the Division of Biomedical Technology and Gyogwon Koo from the Division of Intelligent Robot at DGIST (under President Kunwoo Lee) has developed a technology that distinguishes lung cancer gene mutations solely by measuring the "stiffness" of exosomes-tiny particles released from cancer cells in the bloodstream-using atomic force microscopy (AFM).

30 Jul 2025

Vanderbilt team explores functional β-cell enhancement for diabetes

If it has seemed like more people you know are developing diabetes, you are right. The diabetes epidemic is not called that for nothing: According to the American Diabetes Association, over 10 percent of the U.S. population-approximately 38.4 million people-had diabetes in 2021, and 1.2 million more people get diagnosed each year.

30 Jul 2025

Genetic profiling offers hope for understanding multiple sclerosis risk

In a major step towards early detection, University of South Australia researchers are investigating the biology behind multiple sclerosis (MS) to help predict people's genetic risk of developing the disease, long before any symptoms appear.

29 Jul 2025

Tiny artificial cells successfully mimic biological clocks

A team of UC Merced researchers has shown that tiny artificial cells can accurately keep time, mimicking the daily rhythms found in living organisms.

29 Jul 2025

NR2F1 drives fibrotic cataract formation through activation of STAT3

Cataracts remain one of the most prevalent and debilitating eye conditions, often requiring surgical intervention to restore sight. Yet even after surgery, many patients develop anterior subcapsular cataracts (ASC), characterized by fibrotic tissue growth beneath the lens capsule.

29 Jul 2025

Senescent macrophages emerge as key drivers of tumor progression

Macrophages are versatile immune cells, tasked with cleaning up pathogens and maintaining tissue health.

29 Jul 2025

Groundbreaking Living Brain Project challenges decades of assumptions in neuroscience

In a revealing Genomic Press Interview published today in Genomic Psychiatry, Dr. Alexander W. Charney describes how treating patients with schizophrenia transformed his scientific pursuits from abstract questions to an urgent mission, ultimately leading to discoveries that challenge fundamental assumptions in neuroscience research.

29 Jul 2025

Centauri Therapeutics receives an additional $5.1 M from CARB-X to progress ABX-01 lead compound to first in human clinical trials

Centauri Therapeutics Limited ('Centauri'), an immunotherapy company with a unique and proprietary platform technology applicable across a wide range of therapeutic indications, announced today that CARB-X (Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator) has provided an additional $5.1 M in funding for the development of their lead compound.

29 Jul 2025