Genomics

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Researchers discover broad role for DNA-cutting enzyme in driving abnormal genetic rearrangements

Researchers studying a DNA-cutting enzyme with a crucial role in regulating the structure of genes have discovered a broad role for its cutting activity in driving abnormal genetic rearrangements called translocations that cause cancer, including leukemias and solid tumors.

16 Jun 2017

Lack of 'editing' in microRNAs can potentially drive brain cancers

SCIENTISTS in the UK and India have observed a "significant" lack of 'editing' in microRNAs in brain tissue of brain cancer patients.

16 Jun 2017

Viral vectors for gene transfer can travel to distant areas in the brain, study shows

Gene transfer is seen as a hopeful therapy for Alzheimer's and Parkinson's patients. The approach involves using harmless laboratory-produced viruses to introduce important genes into the brain cells.

16 Jun 2017

Nagoya University research identifies skin disease inherited as germline mutation from father

Nagoya University research identified a patient with the whole-body skin disease epidermolytic ichthyosis that had been inherited as a germline mutation from her father with the milder epidermolytic nevus.

16 Jun 2017

Researchers bioengineer human liver tissues that mimic natural development

An international team of researchers bioengineering human liver tissues uncovered previously unknown networks of genetic-molecular crosstalk that control the organ's developmental processes – greatly advancing efforts to generate healthy and usable human liver tissue from human pluripotent stem cells.

15 Jun 2017

New mutation in MUC1 gene could be valuable biomarker for diagnosing kidney disease

Medullary cystic kidney disease type 1 (MCKD1) is a rare genetic kidney disease. Despite this, because it is an autosomal dominant disease, once the mutation is in a family, many family members are affected. Current diagnostic methods discover the disease late in its development.

14 Jun 2017

Study identifies new susceptibility loci for lung cancer

Using the OncoArray genotyping platform developed by multiple cancer consortia, a recent large aggregated genomewide association study identifies new susceptibility loci for lung cancer, the leading cause of cancer mortality worldwide.

14 Jun 2017

Research shows how morphological changes in the brain help shape the human connectome

Exactly when and where individual neurons develop is as important to our understanding of brain diseases as the underlying genetics, experts have shown.

14 Jun 2017

UNC study uncovers crucial function of key enzyme found in virtually all organisms

UNC School of Medicine researchers have cracked a long-standing mystery about an important enzyme found in virtually all organisms other than bacteria.

13 Jun 2017

Impairment of specific gene increases susceptibility to opioid addiction and binge eating, study shows

Impairment of a particular gene raises increases susceptibility to opioid addiction liability as well as vulnerability to binge eating according to a new study.

13 Jun 2017

Study uncovers new genetic markers linked to testicular germ cell tumors

Testicular cancer is relatively rare with only 8,850 cases expected this year in the United States. A majority of testicular cancer, 95 percent of all cases, begins in testicular germ cells, which are the cells responsible for producing sperm.

13 Jun 2017

Poor diet may fuel Alzheimer's in people who carry disease-related gene

A diet high in cholesterol, fat and sugar may influence the development of Alzheimer's disease in people who carry the ApoE4 gene, a leading risk factor for the memory-erasing disease, indicates a new USC study.

13 Jun 2017

Study finds that e-cigarettes are potentially as harmful as tobacco cigarettes in damaging DNA

A study by chemists at the University of Connecticut (UConn) offers new evidence that e-cigarettes loaded with a nicotine-based liquid are potentially as harmful as unfiltered cigarettes when it comes to causing DNA damage.

13 Jun 2017

Scientists create method for mapping genome-wide DNA damage caused by chemical carcinogen

Scientists have known for decades that smoking cigarettes causes DNA damage, which leads to lung cancer. Now, for the first time, UNC School of Medicine scientists created a method for effectively mapping that DNA damage at high resolution across the genome.

13 Jun 2017

Genetic testing getting better at identifying testicular cancer risk

Testing for a new group of genes associated with testicular cancer has improved the ability to identify men at greatest risk of the disease, say researchers. Scientists at The Institute of Cancer Research, London, found that by testing for 19 new genetic factors in addition to the 25 risk genes already known, they could identify the 1% of men at highest risk.

13 Jun 2017

Developing synthetic mediums for growing organoids

Organoids are bits of tissue grown in vitro, in a near-physiological 3D setting. The particularity consists in the fact that organoids retain features of the patient they are derived from, even when cultured outside of the human body. This is very different from what traditional, conventional cell culture has been able to do over the past 50 years or so.

13 Jun 2017

Genomics

Researchers discover broad role for DNA-cutting enzyme in driving abnormal genetic rearrangements

Lack of 'editing' in microRNAs can potentially drive brain cancers

Viral vectors for gene transfer can travel to distant areas in the brain, study shows

Nagoya University research identifies skin disease inherited as germline mutation from father

Researchers bioengineer human liver tissues that mimic natural development

New mutation in MUC1 gene could be valuable biomarker for diagnosing kidney disease

Study identifies new susceptibility loci for lung cancer

Research shows how morphological changes in the brain help shape the human connectome

UNC study uncovers crucial function of key enzyme found in virtually all organisms

Impairment of specific gene increases susceptibility to opioid addiction and binge eating, study shows

Study uncovers new genetic markers linked to testicular germ cell tumors

Poor diet may fuel Alzheimer's in people who carry disease-related gene

Study finds that e-cigarettes are potentially as harmful as tobacco cigarettes in damaging DNA

Scientists create method for mapping genome-wide DNA damage caused by chemical carcinogen

Genetic testing getting better at identifying testicular cancer risk

Developing synthetic mediums for growing organoids

Dietary practices get reflected in the genes of Europeans, study reveals

Penn analysis finds genetic factors that could help identify men at increased risk for testicular cancer

Researchers uncover seven risk genes for insomnia

Anorexia nervosa linked to genetic anomalies on chromosome 12

Scaling organ‑chip technology for human‑relevant drug discovery

Unlocking drug amorphization: Continuous, solvent-free twin screw granulation

How can super-resolution technology help study neurotransmission?

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