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Bacteria-based cancer therapy achieves tumor eradication without immune cells

A joint research team led by Professor Eijiro Miyako of the Japan Advanced Institute of Science and Technology (JAIST), in collaboration with Daiichi Sankyo Co., Ltd. and University of Tsukuba, has developed a groundbreaking immune-independent bacterial cancer therapy using a novel microbial consortium called AUN.

5 Aug 2025

Ultrasound waves activate brain circuits in living animals for the first time

A new study provides the first visual evidence showing that brain circuits in living animals can be activated by ultrasound waves projected into specific patterns (holograms).

5 Aug 2025

New insights into how genes influence frailty in older adults

A new study has identified genetic variants linked to brain function, immune defense and metabolism that contribute to the development of frailty in older people.

5 Aug 2025

Timing of sexual history influences partner choice across cultures

A major international study has found that when it comes to choosing a long-term partner, people across the globe consider not just how many sexual partners someone has had, but also when those encounters took place.

5 Aug 2025

Vagus nerve stimulation enhances the effects of compassion meditation training

Stimulating the vagus nerve with a device attached to the outer ear can help make compassion meditation training more effective at boosting people's capacity for self-kindness and mindfulness, finds a new study led by University College London (UCL) researchers.

5 Aug 2025

Gfi1 regulates exhausted CD8+ T cells to improve cancer immunotherapy

Killer immune cells destroy cancer cells and cells infected by virus. These CD8+ T cells are activated after detection of viral infection or growth of "non-self" tumor cells.

5 Aug 2025

'Two-in-one' RNA molecule can simultaneously turn off two difficult-to-target cancer-related genes

University of North Carolina Lineberger Comprehensive Cancer Center researchers have developed a "two-in-one" molecule that can simultaneously turn off two notoriously difficult-to-target cancer-related genes, KRAS and MYC, as well as directly deliver drugs to tumors that express these genes.

4 Aug 2025

New treatment approach developed to prevent lupus nephritis

At the time when patients with lupus, or systemic lupus erythematosus (SLE), are diagnosed, approximately 15% to 30% will already have the inflammation-caused kidney disease lupus nephritis, which compromises kidney function and can lead to kidney failure.

4 Aug 2025

New insights reveal how sugar metabolism protects neurons from degeneration

Unlike most cells in the human body, neurons-the functional cells of our nervous system-cannot typically replace themselves with healthy copies after being damaged.

4 Aug 2025

Natural brain rhythms control stress hormone levels and alertness

Ōtākou Whakaihu Waka-led research has found stress-controlling brain cells switch on and off in a steady rhythm about once every hour – even when nothing stressful is happening.

4 Aug 2025

Leptin could offer alternative to insulin for managing type 1 diabetes complication

More than a decade ago, researchers found that an acute complication of type 1 diabetes, diabetic ketoacidosis (DKA), can be resolved with the hormone leptin, even in the absence of insulin.

4 Aug 2025

New brainwave marker identified for Alzheimer’s detection

Using a custom-built tool to analyze electrical activity from neurons, researchers at Brown University have identified a brain-based biomarker that could be used to predict whether mild cognitive impairment will develop into Alzheimer's disease.

4 Aug 2025

New analgesic shows promise as opioid alternative

Opioids like morphine are widely used in medical practice due to their powerful pain-relieving effects. However, they carry the risk of serious adverse effects such as respiratory depression and drug dependence.

4 Aug 2025

Sleep strengthens motor learning through targeted brain rhythms

When faced with difficult tasks, sometimes people hit a mental wall and make the decision to "sleep on it." Returning to the task after sleeping, they often perform better. Why? Rhythmic brain activity during sleep transforms task-related information into stronger, longer-term memory.

4 Aug 2025

Targeted botox delivery shows promise for treating jaw disorder

Temporomandibular disorder (TMD) limits jaw function and is so painful that it lessens the quality of life.

4 Aug 2025

Mouth and gut microbes talk to each other - here’s why it matters for disease

Researchers reviewed nearly 250 studies to uncover how the oral and gut microbiomes communicate through multiple pathways, influencing the risk of diseases such as IBD, colorectal cancer, and cardiovascular disorders. The review highlights that maintaining oral health and dietary habits is crucial for overall systemic wellbeing.

4 Aug 2025

Scientists reveal how rare gene mutations drive schizophrenia risk

Researchers analyzed the largest exome-sequencing dataset to date and identified new rare coding variants and genes linked to schizophrenia risk. The study highlights converging genetic pathways, implicating chromatin organization and GABAergic signaling in schizophrenia neurobiology.

4 Aug 2025

Impulsivity shapes diet and gut bacteria in healthy adults, study finds

Impulsivity in healthy adults is linked to unhealthy dietary choices, such as higher intake of alcohol and sugary drinks and lower fiber consumption. These dietary behaviors, in turn, are associated with changes in specific gut bacterial genera, highlighting an indirect pathway between personality traits and the gut microbiome.

4 Aug 2025

HIV trial points to semaglutide as a new anti-aging contender

Once-weekly semaglutide significantly slowed epigenetic aging in adults with HIV-associated lipohypertrophy, as measured by multiple DNA methylation clocks in a randomized controlled trial. These exploratory findings suggest GLP-1 receptor agonists could impact biological aging but require further validation in broader populations.

4 Aug 2025

UCLA study shows stem cells can be reprogrammed to fight cancer

In a first-of-its-kind clinical trial, UCLA scientists have shown it's possible to reprogram a patient's blood-forming stem cells to generate a continuous supply of functional T cells, the immune system's most powerful cancer-killing agents.

4 Aug 2025