Colorectal Cancer

Colorectal Cancer is cancer that develops in the colon (the longest part of the large intestine) and/or the rectum (the last several inches of the large intestine before the anus). In the United States, it is the fourth most common cancer in men and women. Caught early, it is often curable.

What Causes Colorectal Cancer?

Cancer occurs when a normal cell divides and multiples uncontrollably. Normally cells are regulated in their growth, maturity, division and death by the DNA present in their nucleus. With damage to the DNA the cells may become rogue and multiply uncontrollably to give rise to tumors.

Microbial Dysbiosis and Colorectal Cancer

Colorectal Cancer Pathogenesis

Colorectal Cancer Symptoms

Colorectal Cancer Prevention

Colorectal Cancer and Organ Preservation

Colorectal Cancer Management

Colorectal Cancer Prognosis

What is Colorectal Cancer?

Colorectal Cancer Diagnosis

Latest Colorectal Cancer News and Research

Novel insights from lymphoid structures: Lessons from colorectal cancer research

Discover how lymphoid structures and germinal centers provide powerful prognostic insights into colorectal cancer.

From TissueGnostics 31 Jul 2025

Harnessing the power of gut bacteria to enhance cancer immunotherapy effectiveness

A comprehensive new review reveals both the promise and challenges of using fecal microbiota transplantation (FMT) to enhance cancer immunotherapy effectiveness.

30 Jul 2025

Study identifies risk factors for second colorectal cancer in people with Lynch syndrome

A current study by the German Familial Colorectal Cancer Consortium is looking at the question of which people with Lynch syndrome are at an increased risk of developing a second colorectal cancer.

30 Jul 2025

Blood-based tests show promise for colorectal cancer screening but follow-up challenges persist

A study led by investigators at the UCLA Health Jonsson Comprehensive Cancer Center found that while blood-based tests offer a more convenient option for colorectal cancer screening, only 49% of patients completed a follow-up colonoscopy within six months, and just 56% did so at any point during the two-year study period.

29 Jul 2025

Most dairy foods linked to neutral or better health but yogurt stands out for real benefits

A major scoping review of recent systematic reviews and meta-analyses finds that most dairy products are either neutral or modestly protective for heart, cancer, metabolic, and mortality outcomes in adults. Yogurt and other fermented dairy consistently show the strongest health associations, while some risks remain for specific cancers.

28 Jul 2025

Advancing precision medicine in colorectal cancer with multi-omics approaches

Colorectal cancer is among the most prevalent and lethal malignancies worldwide, with liver metastases occurring in nearly one-third of patients and accounting for a major share of cancer-related deaths.

28 Jul 2025

Blocking a single gene disrupts vitamin D metabolism and cancer pathways in new cell study

Researchers identified SDR42E1 as a key regulator of vitamin D absorption and sterol metabolism in colorectal cancer cells. Disruption of this enzyme altered cancer-related pathways and cell viability, highlighting its potential as a therapeutic target.

21 Jul 2025

Rare coexistence of APC and KRAS mutations observed in patient with FAP and endometrial cancer

Researchers have discovered an unusual case where two well-known cancer-related mutations-APC and KRAS-coexisted in a woman with familial adenomatous polyposis (FAP) and a history of endometrial cancer.

18 Jul 2025

Study reveals complex patterns of burden and survival among people with digestive system cancers in China

Digestive system malignancies (DSMTs)-including esophageal, gastric, colorectal, liver, and pancreatic cancers-represent a major public health challenge in China.

18 Jul 2025

Cuproptosis offers new hope for treating inflammatory bowel disease and colorectal cancer

Cuproptosis represents a novel mechanism of cell death characterized by intracellular copper ion accumulation.

18 Jul 2025

Study identifies SDR42E1's role in vitamin D pathway

Vitamin D is not only an essential nutrient, but also the precursor of the hormone calcitriol, indispensable for health: it regulates the uptake of phosphate and calcium necessary for bones by the intestines, as well as cell growth and the proper function of muscles, nerve cells, and the immune system.

18 Jul 2025

New reviews highlight urgent need for GI cancer screening in younger adults

Early-onset gastrointestinal (GI) cancers are rising at alarming rates worldwide and, in the U.S., are increasing faster than any other type of early-onset cancer, including breast cancer, according to two recent literature reviews from Dana-Farber Cancer Institute.

17 Jul 2025

Viome and Scripps Research join forces to develop at-home RNA test for colon cancer prevention

Viome Life Sciences, the leader in AI-powered, RNA-based diagnostics and precision nutrition and Scripps Research, the leader in accelerating the impact of fundamental research on human health, today announced a strategic partnership to develop and clinically validate the first at-home RNA test designed to detect precancerous colon polyps, enabling early prevention of colorectal cancer.

14 Jul 2025

Pathogenic mechanisms of Fusobacterium nucleatum in colorectal cancer and emerging therapies

In recent years, the regulatory role of the gut microbiota in the initiation and progression of colorectal cancer (CRC) has attracted growing attention. Among the key microbial contributors, Fusobacterium nucleatum (Fn) has been identified as a critical pathogenic factor in CRC.

12 Jul 2025

Shen-Bai-Jie-Du decoction inhibits colorectal tumorigenesis by targeting immunosuppressive dendritic cells

This new article publication from Acta Pharmaceutica Sinica B, discusses how single-cell RNA sequencing reveals that Shen-Bai-Jie-Du decoction retards colorectal tumorigenesis by regulating the TMEM131-TNF signaling pathway-mediated differentiation of immunosuppressive dendritic cells.

12 Jul 2025

New biosensor uses light and AI to detect cancer in its earliest stages

Dr. Ho Sang Jung and his research team from the Advanced Bio and Healthcare Materials Research Division at the Korea Institute of Materials Science(KIMS) have developed an optical biosensor capable of detecting trace amounts of cancer cell DNA in the bloodstream with high sensitivity, enabling early cancer diagnosis.

10 Jul 2025

Many Americans misunderstand the health impact of processed foods

Thirty-nine percent of respondents to an online poll incorrectly said all processed foods are unhealthy, according to new research by the Physicians Committee for Responsible Medicine published today, July 8, 2025, in JAMA Network Open.

9 Jul 2025

New RNA-based liquid biopsy detects early colorectal cancer with high accuracy

Liquid biopsies are tests that detect signs of cancer through a simple blood draw. Unlike traditional biopsies, which require removing a piece of tissue, a liquid biopsy typically looks for mutations or modification changes in fragments of DNA from cancer cells circulating in the blood.

8 Jul 2025

Early-onset gastrointestinal cancer rates rising across the globe

A new paper in BJS, published by Oxford University Press, indicates that early-onset gastrointestinal cancer rates are rising dramatically across the globe.

8 Jul 2025

Harnessing the gut virome emerges as a promising strategy in precision medicine

The human gut is home to trillions of microbes, yet scientific understanding has largely focused on bacteria, leaving the virome—the community of viruses—relatively uncharted.

3 Jul 2025

Colorectal Cancer

Overview

Microbial Dysbiosis and Colorectal Cancer

Colorectal Cancer Pathogenesis

Colorectal Cancer Symptoms

Feature Articles

Colorectal Cancer Prevention

Colorectal Cancer and Organ Preservation

Colorectal Cancer Management

Colorectal Cancer Prognosis

What is Colorectal Cancer?

Colorectal Cancer Diagnosis

Latest Colorectal Cancer News and Research

Novel insights from lymphoid structures: Lessons from colorectal cancer research

Harnessing the power of gut bacteria to enhance cancer immunotherapy effectiveness

Study identifies risk factors for second colorectal cancer in people with Lynch syndrome

Blood-based tests show promise for colorectal cancer screening but follow-up challenges persist

Most dairy foods linked to neutral or better health but yogurt stands out for real benefits

Advancing precision medicine in colorectal cancer with multi-omics approaches

Blocking a single gene disrupts vitamin D metabolism and cancer pathways in new cell study

Rare coexistence of APC and KRAS mutations observed in patient with FAP and endometrial cancer

Study reveals complex patterns of burden and survival among people with digestive system cancers in China

Cuproptosis offers new hope for treating inflammatory bowel disease and colorectal cancer

Study identifies SDR42E1's role in vitamin D pathway

New reviews highlight urgent need for GI cancer screening in younger adults

Viome and Scripps Research join forces to develop at-home RNA test for colon cancer prevention

Pathogenic mechanisms of Fusobacterium nucleatum in colorectal cancer and emerging therapies

Shen-Bai-Jie-Du decoction inhibits colorectal tumorigenesis by targeting immunosuppressive dendritic cells

New biosensor uses light and AI to detect cancer in its earliest stages

Many Americans misunderstand the health impact of processed foods

New RNA-based liquid biopsy detects early colorectal cancer with high accuracy

Early-onset gastrointestinal cancer rates rising across the globe

Harnessing the gut virome emerges as a promising strategy in precision medicine

Industry Focus eBook: Oncology eBook

Unlocking drug amorphization: Continuous, solvent-free twin screw granulation

How can super-resolution technology help study neurotransmission?

The Proteoform Puzzle: Unlocking the Next Frontier

Colorectal Cancer

Overview

Feature Articles

Colorectal Cancer Prevention

Colorectal Cancer and Organ Preservation

Colorectal Cancer Management

Colorectal Cancer Prognosis

What is Colorectal Cancer?

Colorectal Cancer Diagnosis

Latest Colorectal Cancer News and Research

Industry Focus eBook: Oncology eBook

Unlocking drug amorphization: Continuous, solvent-free twin screw granulation

How can super-resolution technology help study neurotransmission?

The Proteoform Puzzle: Unlocking the Next Frontier

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