Dendritic Cell News and Research

Latest Dendritic Cell News and Research

Evolution of vaccine adjuvants from empirical discovery to rational design

Vaccine adjuvants have evolved significantly since their inception, transitioning from empirical discovery to a more structured approach grounded in rational drug design.

13 Sep 2024

The interplay of liver cancer stem cells and immune cells in tumor microenvironment

The complex dynamics between liver cancer stem cells (CSCs) and immune cells within the tumor microenvironment (TME) are central to the progression of liver cancer. These interactions are critical in creating an immunosuppressive setting that significantly impacts the response to immunotherapy. Liver CSCs, responsible for tumor initiation, metastasis, therapeutic resistance, and recurrence, exhibit heterogeneity and are characterized by various surface markers that contribute to their stemness and metastatic potential.

7 Aug 2024

UCLA launches groundbreaking clinical trial for vaccine targeting aggressive pediatric brain cancer

In an effort to combat one of the most lethal forms of pediatric brain cancer, researchers at the UCLA Health Jonsson Comprehensive Cancer Center are launching a first-of-its-kind clinical trial to evaluate the safety and effectiveness of a cancer vaccine targeting H3 G34-mutant diffuse hemispheric glioma, a highly aggressive brain tumor that is typically found in adolescents and young adults.

5 Aug 2024

AI reprograms glioblastoma cells into dendritic cells for cancer immunotherapy

In an innovative new study of glioblastoma, scientists used artificial intelligence (AI) to reprogram cancer cells, converting them into dendritic cells (DCs), which can identify cancer cells and direct other immune cells to kill them.

31 Jul 2024

Triad of immune cells key to successful cancer immunotherapy, study finds

There's a frustrating fact about today's immunotherapies for cancer. While sometimes they work beautifully - completely eliminating or greatly reducing cancer in particular patients - other times they don't work at all. It's a mystery.

15 Jul 2024

Study reveals early immune responses to SARS-CoV-2, offering insights for future COVID-19 treatments

Researchers analyzed early immune responses to SARS-CoV-2 using single-cell multi-omics, revealing key cellular states associated with different infection outcomes.

24 Jun 2024

‘Artificial lymph node’ shows potential to treat cancer

Johns Hopkins Medicine scientists say they have developed an artificial lymph node with the potential to treat cancer, according to a new study in mice and human cells.

6 Jun 2024

How tight binding between immune cells dictates T cell cancer-fighting ability

Immunotherapy, treatments that reinvigorate immune cells' anti-cancer activity or reprogram T cells to target cancer, has shown promise in treating leukemias but has not yet been realized in solid tumors.

30 May 2024

Exercise-induced exerkines: Secret weapon in disease prevention and therapy

A recent review in Signal Transduction and Targeted Therapy highlights the role of exercise-induced molecules, exerkines, in disease prevention and treatment, emphasizing their molecular mechanisms and therapeutic potential.

29 May 2024

Combination immunotherapy treatment enhances immune response for people with malignant gliomas

Investigators at the UCLA Health Jonsson Comprehensive Cancer Center have pinpointed a combination immunotherapy treatment that enhances the immune response for people with malignant gliomas, an aggressive type of brain tumor that is fast growing and difficult to treat.

9 May 2024

Bacterial fatty acid metabolite identified as key player in immune regulation

Gut microbiota or the population of microbial inhabitants in the intestine, plays a key role in digestion and maintenance of overall health.-

7 May 2024

Liver cells effectively serve as immune checkpoint regulating anti-cancer immunity

Liver inflammation, a common side-effect of cancers elsewhere in the body, has long been associated with worse cancer outcomes and more recently associated with poor response to immunotherapy.

22 Apr 2024

New trials show promise for immune checkpoint blockers in early-stage lung cancer

A dendritic cell (DC) vaccine targeting patient-specific neoantigens to patients with resected non-small cell lung cancer (NSCLC).

18 Apr 2024

CPRIT awards MD Anderson 16 grants to support cancer research and prevention

The University of Texas MD Anderson Cancer Center today was awarded 16 grants totaling over $25.5 million from the Cancer Prevention and Research Institute of Texas (CPRIT) in support of cancer screening, early detection and prevention programs, faculty recruitment, and groundbreaking cancer research across all areas of the institution.

21 Feb 2024

How immune cells shape our earliest breaths

Study profiles the development of immune cells in human lungs during embryonic and fetal stages, revealing their influence on epithelial cell fate and lung development.

1 Jan 2024

New optimized vaccine approach targets Hepatitis C virus variability

A method to design vaccines for highly variable viruses like the hepatitis C virus.

12 Dec 2023

Revolutionary advances in psoriasis treatment: unveiling new therapeutic approaches

Psoriasis etiopathogenesis and treatment.

29 Nov 2023

Short-chain fatty acids produced by intestinal bacteria play role in dendritic cell elongation

Dendritic cells play a key role in the mammalian immune system. These cells are present throughout the human body and are known to capture foreign bodies, i.e., antigens, using extendable "arms" called dendrites.

30 Oct 2023

Pitt scientists develop new approach to reduce side effects of organ transplants

Giving living donor liver transplant recipients an infusion of immune cells derived from their donor a week before transplantation is feasible, safe – and may lead to recipients being successfully weaned off immunosuppressant medications without rejecting the transplanted organ.

11 Oct 2023

Radiation therapy combined with two types of immunotherapy could be effective against cold tumors

Researchers at Weill Cornell Medicine have discovered that radiation therapy combined with two types of immunotherapy - one that boosts T cells, and another that boosts dendritic cells - can control tumors in preclinical models of triple negative breast cancer, a cancer type that's typically resistant to immunotherapy alone.

25 Sep 2023

Dendritic Cell News and Research

Latest Dendritic Cell News and Research

Evolution of vaccine adjuvants from empirical discovery to rational design

The interplay of liver cancer stem cells and immune cells in tumor microenvironment

UCLA launches groundbreaking clinical trial for vaccine targeting aggressive pediatric brain cancer

AI reprograms glioblastoma cells into dendritic cells for cancer immunotherapy

Triad of immune cells key to successful cancer immunotherapy, study finds

Study reveals early immune responses to SARS-CoV-2, offering insights for future COVID-19 treatments

‘Artificial lymph node’ shows potential to treat cancer

How tight binding between immune cells dictates T cell cancer-fighting ability

Exercise-induced exerkines: Secret weapon in disease prevention and therapy

Combination immunotherapy treatment enhances immune response for people with malignant gliomas

Bacterial fatty acid metabolite identified as key player in immune regulation

Liver cells effectively serve as immune checkpoint regulating anti-cancer immunity

New trials show promise for immune checkpoint blockers in early-stage lung cancer

CPRIT awards MD Anderson 16 grants to support cancer research and prevention

How immune cells shape our earliest breaths

New optimized vaccine approach targets Hepatitis C virus variability

Revolutionary advances in psoriasis treatment: unveiling new therapeutic approaches

Short-chain fatty acids produced by intestinal bacteria play role in dendritic cell elongation

Pitt scientists develop new approach to reduce side effects of organ transplants

Radiation therapy combined with two types of immunotherapy could be effective against cold tumors

Immunology eBook

Scaling organ‑chip technology for human‑relevant drug discovery

Unlocking drug amorphization: Continuous, solvent-free twin screw granulation

How can super-resolution technology help study neurotransmission?

Dendritic Cell News and Research

Latest Dendritic Cell News and Research

Immunology eBook

Scaling organ‑chip technology for human‑relevant drug discovery

Unlocking drug amorphization: Continuous, solvent-free twin screw granulation

How can super-resolution technology help study neurotransmission?

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