Pharmacology News and Research

Latest Pharmacology News and Research

TTUHSC researcher focuses on how brain endothelial cells handle stressors of neuroinflammation

Each year in the U.S., approximately 2.5 million people suffer traumatic brain injuries (TBIs). About 50,000 of these injuries will result in death, and more than 80,000 will lead to permanent disability.

16 Jul 2025

New review identifies promising and under-researched OTC depression aids

Most people have heard of St John's Wort and omega-3s. But did you know there are a lot more over-the-counter herbal products and supplements out there targeting depression? In our review of clinical trials of these products, we found 64 different over-the-counter (OTC) products that have been evaluated for depression – but with differing levels of evidence for each.

16 Jul 2025

Therapeutic potential of houttuynia cordata polysaccharide in H1N1 and MRSA-induced acute pneumonia

This new article publication from Acta Pharmaceutica Sinica B, discusses how an anti-complement homogeneous polysaccharide from Houttuynia cordata ameliorates acute pneumonia with H1N1 and MRSA coinfection through rectifying Treg/Th17 imbalance in the gut–lung axis and NLRP3 inflammasome activation.

12 Jul 2025

ALKBH3 regulates glycolysis and doxorubicin resistance in triple negative breast cancer

This new article publication from Acta Pharmaceutica Sinica B, discusses how ALKBH3-regulated m1A of ALDOA potentiates glycolysis and doxorubicin resistance of triple negative breast cancer cells.

12 Jul 2025

Shen-Bai-Jie-Du decoction inhibits colorectal tumorigenesis by targeting immunosuppressive dendritic cells

This new article publication from Acta Pharmaceutica Sinica B, discusses how single-cell RNA sequencing reveals that Shen-Bai-Jie-Du decoction retards colorectal tumorigenesis by regulating the TMEM131-TNF signaling pathway-mediated differentiation of immunosuppressive dendritic cells.

12 Jul 2025

Melatonin receptor signaling counters sleep fragmentation-mediated infertility in T2DM

This new article publication from Acta Pharmaceutica Sinica B, discusses how melatonin receptor 1a alleviates sleep fragmentation-aggravated testicular injury in T2DM by suppression of TAB1/TAK1 complex through FGFR1.

12 Jul 2025

High-intensity focused ultrasound induces ferroptosis for tumor immune activation

This new article publication from Acta Pharmaceutica Sinica B, discusses high intensity forced ultrasound-driven ferroptosis as a strategy for anti-tumor immune priming.

12 Jul 2025

Engineered exosomal spheres enhance melanoma immunotherapy through improved tumor penetration

This new article publication from Acta Pharmaceutica Sinica B, discusses the use of engineered platelet-derived exosomal spheres for enhanced tumor penetration and extended circulation in melanoma immunotherapy.

12 Jul 2025

CMD-OPT model enables discovery of potent and selective RIPK2 inhibitor for acute liver injury

This new article publication from Acta Pharmaceutica Sinica B, discusses how a CMD-OPT model enables the discovery of a potent and selective RIPK2 inhibitor as preclinical candidate for the treatment of acute liver injury.

12 Jul 2025

Composite HA-SF hydrogel provides natural and durable anti-aging solution

This new article publication from Acta Pharmaceutica Sinica B, discusses a high clinically translatable strategy to anti-aging using hyaluronic acid and silk fibroin co-crosslinked hydrogels as dermal regenerative fillers.

12 Jul 2025

Scientists uncover key role of cypin in strengthening brain cell connections

Scientists have discovered how a key protein helps maintain strong connections between brain cells that are crucial for learning and memory.

11 Jul 2025

Targeting SRSF7 offers potential therapy for pulmonary fibrosis

This new article publication from Acta Pharmaceutica Sinica B, discusses how SRSF7 promotes pulmonary fibrosis through regulating PKM alternative splicing in lung fibroblasts.

10 Jul 2025

Psychological stress drives ovarian tumor metastasis through NR3C1 and NUPR1

This new article publication from Acta Pharmaceutica Sinica B, discusses how a psychological stress-activated NR3C1/NUPR1 axis promotes ovarian tumor metastasis.

10 Jul 2025

Uncovering how a key inflammatory molecule causes esophageal smooth muscle contractions

A research group led by Dr. Keisuke Obara, Dr. Kento Yoshioka, and Professor Yoshio Tanaka from the Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, has uncovered important details about how platelet-activating factor (PAF)-a powerful molecule involved in inflammation and allergic reactions-triggers contractions in the smooth muscles of the esophagus.

9 Jul 2025

Experimental treatment reverses paralysis in child with rare mitochondrial disease

The value of a recent biochemical discovery can be seen in the case of an 8-year-old boy. In August 2023 he was able to play typical sports, but by November he needed a wheelchair because of a rare disease that caused worsening paralysis.

9 Jul 2025

New study identifies factors linked to successful weight loss using GLP-1RAs

A study in Diabetes, Obesity and Metabolism has identified certain characteristics that might influence people's weight loss after taking prescription drugs called glucagon-like peptide-1 receptor agonists (GLP-1RAs), such as semaglutide (sold under the brand names Ozempic and Wegovy).

9 Jul 2025

New TB drugs show promise with fewer side effects than linezolid

The drugs, sutezolid and delpazolid, have demonstrated strong antimicrobial activity and a notably better safety profile compared to linezolid, with potential to replace this current cornerstone in the treatment of drug-resistant TB.

8 Jul 2025

Novel tool offers a glimpse into the black box of ALT in aggressive cancers

Each time a cell divides, a small section of each chromosome's protective cap - the telomere - is worn away. Most cells use an enzyme called telomerase to help mitigate this loss, but 10% to 15% of cancers have another mechanism called the alternative lengthening of telomeres (ALT) pathway.

4 Jul 2025

EU researchers call for wider use of alternatives to animal testing

Researchers examine how the use of animal testing to identify endocrine-disrupting substances in the EU can be reduced. Although it is, in principle, possible to identify such substances without using animals, non-animal methods are still rarely applied.

3 Jul 2025

Embryos from women with PCOS carry distinctive epigenetic memory

Novel research presented today at the 41st Annual Meeting of the European Society of Human Reproduction and Embryology (ESHRE) has found that embryos from women with polycystic ovary syndrome (PCOS) carry a distinctive 'epigenetic memory' that could explain why the condition often runs in families.

1 Jul 2025

Pharmacology News and Research

Latest Pharmacology News and Research

TTUHSC researcher focuses on how brain endothelial cells handle stressors of neuroinflammation

New review identifies promising and under-researched OTC depression aids

Therapeutic potential of houttuynia cordata polysaccharide in H1N1 and MRSA-induced acute pneumonia

ALKBH3 regulates glycolysis and doxorubicin resistance in triple negative breast cancer

Shen-Bai-Jie-Du decoction inhibits colorectal tumorigenesis by targeting immunosuppressive dendritic cells

Melatonin receptor signaling counters sleep fragmentation-mediated infertility in T2DM

High-intensity focused ultrasound induces ferroptosis for tumor immune activation

Engineered exosomal spheres enhance melanoma immunotherapy through improved tumor penetration

CMD-OPT model enables discovery of potent and selective RIPK2 inhibitor for acute liver injury

Composite HA-SF hydrogel provides natural and durable anti-aging solution

Scientists uncover key role of cypin in strengthening brain cell connections

Targeting SRSF7 offers potential therapy for pulmonary fibrosis

Psychological stress drives ovarian tumor metastasis through NR3C1 and NUPR1

Uncovering how a key inflammatory molecule causes esophageal smooth muscle contractions

Experimental treatment reverses paralysis in child with rare mitochondrial disease

New study identifies factors linked to successful weight loss using GLP-1RAs

New TB drugs show promise with fewer side effects than linezolid

Novel tool offers a glimpse into the black box of ALT in aggressive cancers

EU researchers call for wider use of alternatives to animal testing

Embryos from women with PCOS carry distinctive epigenetic memory

Pharmaceutical Manufacturing - Industry Focus eBook eBook

Scaling organ‑chip technology for human‑relevant drug discovery

Unlocking drug amorphization: Continuous, solvent-free twin screw granulation

How can super-resolution technology help study neurotransmission?

Pharmacology News and Research

Latest Pharmacology News and Research

Pharmaceutical Manufacturing - Industry Focus eBook eBook

Scaling organ‑chip technology for human‑relevant drug discovery

Unlocking drug amorphization: Continuous, solvent-free twin screw granulation

How can super-resolution technology help study neurotransmission?

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