Tuberculosis News and Research

Latest Tuberculosis News and Research

New compound infuzide shows promise against resistant bacterial infections

Antimicrobial resistance directly causes more than 1 million deaths every year and contributes to more than 35 million more, according to the World Health Organization. Staphylococcus aureus and Enterococcus sp., 2 gram-positive pathogens highly likely to develop resistance to known treatments, can cause dangerous hospital-acquired and community-acquired infections.

2 Jun 2025

New antibody discovery reveals powerful immune defense against tuberculosis

Researchers at the Ragon Institute have made a significant discovery about how antibodies can directly enhance the body's ability to fight Mycobacterium tuberculosis (Mtb), the bacteria responsible for tuberculosis (TB).

30 May 2025

New insights into decades-old bladder cancer treatment offers clues for immunotherapy

More than three decades ago, the U.S. Food and Drug Administration (FDA) approved Bacillus Calmette-Guérin (BCG) as the first immunotherapy against cancer. And it is still used today to treat early-stage bladder cancer.

29 May 2025

BCG immunotherapy reprograms bone marrow to boost cancer defense

29 May 2025

WHO and African Union renew agreement to strengthen health in Africa

The World Health Organization (WHO) and the African Union (AU) Commission renewed their longstanding strategic partnership today with the signing of an updated Memorandum of Understanding (MoU) on the sidelines of the 78th World Health Assembly in Geneva.

26 May 2025

Novel immune cells identified as potential target for tuberculosis vaccines

There is no highly effective vaccine against tuberculosis (TB), which remains an infection of global concern.

26 May 2025

Metagenomic next-generation sequencing improves pulmonary infection diagnosis

A recent study on the application of Metagenomic next-generation sequencing (mNGS) found that mNGS can achieve early detection of pathogens and accelerate the development of targeted anti-infection treatment plans, thereby improving treatment outcomes and patient prognosis.

23 May 2025

Tuberculosis bacteria use molecular switch to pause and restart growth

The bacteria that cause tuberculosis (TB) may have an "on-off switch" that lets them pause and restart growth, according to a new study from the University of Surrey and the University of Oxford.

23 May 2025

Metabolite profiles in spinal fluid predict mortality in tuberculous meningitis

Radboudumc researchers Kirsten van Abeelen, Edwin Ardiansyah, Sofiati Dian, Vinod Kumar, Reinout van Crevel and Arjan van Laarhoven used metabolomics to study cerebrospinal fluid (CSF) samples from tuberculous meningitis patients in Vietnam and Indonesia, with long-standing collaborators from Bandung and Jakarta (Indonesia), the Broad Institute (Boston) and the Oxford University Research Unit in Ho Chi Minh City (Vietnam).

22 May 2025

HIV vaccine study marks breakthrough in targeting broad immune responses

A decades-long scientific challenge in HIV vaccine development has been finding a way to train the immune system to produce antibodies that can target many variants of the virus.

15 May 2025

New genetic database sheds light on Brazil’s ancestry and disease risks

Since the human genome was first sequenced in 2003, the world's scientific community has been racing to decipher this "book" written in an alphabet of four letters.

15 May 2025

Study reveals key differences in health risks between males and females

The results of an international study led by researchers from Queen Mary University of London's Precision Healthcare University Research Institute (PHURI) shed new light the underlying biological mechanisms which cause differences in health risks, symptoms and outcomes between males and females.

13 May 2025

Anti-parasitic drug could accelerate the elimination of infection endemic to Africa

Tens of millions of people in Africa are infected by parasitic worms that cause lymphatic filariasis (also called elephantiasis), a disease that leads to severe swelling and deformities of the limbs and genitals.

7 May 2025

Scientists engineer new drug candidate to fight deadly mycobacterial infection

In a classic example of scientific problem solving, scientists from the Hackensack Meridian Center for Discovery and Innovation (CDI) and colleagues have published a paper introducing a promising new drug candidate they engineered to target a deadly and emerging infection.

6 May 2025

Breakthrough in labeling TB glycans could lead to faster diagnosis

Tuberculosis, the world's deadliest infectious disease, is estimated to infect around 10 million people each year, and kills more than 1 million annually. Once established in the lungs, the bacteria's thick cell wall helps it to fight off the host immune system.

5 May 2025

New rifamycin drugs fight antibiotic-resistant lung infections more effectively

Researchers have developed next-generation rifamycin analogs that effectively kill both replicating and nonreplicating Mycobacterium abscessus while minimizing drug-drug interactions. Lead candidates UMN-120 and UMN-121 showed superior efficacy to current treatments in mouse models and retained potency against M. tuberculosis.

5 May 2025

New RNA-based diagnostics to fight against tuberculosis

In 2023, tuberculosis (TB) killed about 1.25 million people worldwide, more than any other infectious disease on Earth — even though it is curable. Months- or even years-long regimens of potent antibiotics can eradicate the Mycobacterium tuberculosis bacteria.

25 Apr 2025

New strategy for TB screening aims to save lives

A new strategy for tuberculosis (TB) screening, proposed by a team of researchers led by Queen Mary University of London, provides a solution to problems with current TB screening, which does not always accurately detect disease.

24 Apr 2025

UC3M unveils three scientific research projects to combat tuberculosis

Universidad Carlos III de Madrid (UC3M) has presented three scientific research projects contributing to the fight against tuberculosis, the leading cause of death from infectious disease in the world.

23 Apr 2025

Experimental cancer drug shows promise in boosting tuberculosis treatment

An experimental drug now in clinical trials as a cancer treatment could help boost the power of first-line tuberculosis (TB) treatments by helping infected cells die a gentler death, Johns Hopkins Medicine investigators report, based on mouse-model research of the lung-damaging disease.

21 Apr 2025