Cirrhosis

Cirrhosis is a condition in which the liver slowly deteriorates and malfunctions due to chronic injury. Scar tissue replaces healthy liver tissue, partially blocking the flow of blood through the liver.

What is Cirrhosis?

Cirrhosis is a severe form of liver disease wherein normal liver tissue is replaced by scar tissue (fibrous tissue).

Liver Disease Symptoms

Managing and Treating Cirrhosis

What Causes Cirrhosis?

Scarred liver tissue creates fertile ground for cancer development

Over 80% of hepatocellular carcinoma (HCC) – the third-leading cause of cancer deaths globally – emerges from advanced liver fibrosis or cirrhosis. A comprehensive review in Hepatology International synthesizes decades of research to reveal how scarred liver tissue becomes a breeding ground for cancer.

31 Jul 2025

WHO urges urgent action to eliminate hepatitis and reduce liver cancer deaths

As we mark World Hepatitis Day, WHO calls on governments and partners to urgently accelerate efforts to eliminate viral hepatitis as a public health threat and reduce liver cancer deaths.

29 Jul 2025

Study finds significant associations between sleep traits and 172 diseases

A groundbreaking international study, recently published in Health Data Science, analyzed objective sleep data from 88,461 adults in the UK Biobank and found significant associations between sleep traits and 172 diseases.

28 Jul 2025

Vitamin D supplementation reduces liver inflammation and fibrosis largely through TXNIP

Chronic liver disease (CLD) is a major global health concern, affecting approximately 1.5 billion people. This life-threatening disease often progresses silently, eventually leading to worsened conditions like liver cirrhosis or liver cancer.

28 Jul 2025

AI tool helps doctors predict hospital death risk in cirrhosis patients

Predicting who might die while in the hospital is one of the hardest challenges for doctors caring for people with serious liver disease.

24 Jul 2025

Machine learning improves prediction of death risk in hospitalized cirrhosis patients

Researchers employed a machine learning technique known as random forest analysis and found that it significantly outperformed traditional methods in predicting which hospitalized patients with cirrhosis are at risk of death, according to a new paper published in Gastroenterology.

23 Jul 2025

Study reveals how aging alters liver function and structure

The aging liver undergoes dramatic changes in its functional organization and other key attributes, which may underpin its increasing susceptibility to disease, according to a study led by investigators at Weill Cornell Medicine.

17 Jul 2025

New molecular pathway identified in alcohol-associated liver disease

Excessive alcohol consumption causes alcoholic liver disease, and about 20% of these cases progress to alcohol-associated steatohepatitis (ASH), which can lead to liver cirrhosis and liver failure. Early diagnosis and treatment are therefore extremely important.

17 Jul 2025

Exploring the roles of orphan nuclear receptors in MASLD pathogenesis

Metabolic dysfunction-associated steatotic liver disease (MASLD), affecting approximately 30% of the global population, represents a spectrum of liver disorders ranging from simple steatosis to metabolic dysfunction-associated steatohepatitis (MASH), fibrosis, and cirrhosis.

12 Jul 2025

Hepatitis C treatment gaps persist for children and new mothers

As the opioid epidemic has worsened in the United States, prevalence of hepatitis C has also increased. Hepatitis C is a bloodborne virus that damages the liver.

11 Jul 2025

Short-term exercise improves liver health by modulating amino acid metabolism

Metabolic-associated steatohepatitis (MASH) is an advanced and progressive liver disease that potentially causes cirrhosis and hepatocellular carcinoma.

10 Jul 2025

Improving fatty liver diagnosis through AI analysis of standard chest radiographs

Fatty liver disease, caused by the accumulation of fat in the liver, is estimated to affect one in four people worldwide. If left untreated, it can lead to serious complications, such as cirrhosis and liver cancer, making it crucial to detect early and initiate treatment.

27 Jun 2025

Ribosome biogenesis plays critical role in liver health and disease progression

This new review article highlights the critical role of ribosome biogenesis in liver health and disease progression.

25 Jun 2025

New molecular imaging agent shows high accuracy in detecting liver cancer

A novel molecular imaging agent targeting glypican-3 (GPC3) has demonstrated high sensitivity and specificity in detecting hepatocellular carcinoma (HCC), including tumors smaller than one centimeter, according to results from a pilot clinical study.

23 Jun 2025

New intercellular network found to drive liver fibrosis progression

Liver fibrosis, a pathological condition in which the liver becomes stiff and scarred, commonly develops in the progression of chronic liver diseases such as chronic hepatitis and metabolic dysfunction-associated steatohepatitis (MASH).

21 Jun 2025

Circular RNAs emerge as key players in hepatitis B-related liver cancer

Hepatitis B virus-induced hepatocellular carcinoma (HCC) remains a major global health burden, and new therapeutic and diagnostic approaches are urgently needed.

20 Jun 2025

Fatty liver found in majority of type 2 diabetes patients

Six out of ten people with type 2 diabetes had fatty liver in a new study from Linköping University. Of these, only a small percentage had developed more severe liver disease.

17 Jun 2025

Chronic hyponatremia causes anxiety-like behaviors by disrupting brain chemistry

Hyponatremia, or low blood sodium concentration, is typically viewed as a symptomless condition-until recently.

12 Jun 2025

Waist-to-height ratio found to predict liver damage better than BMI

Excess fat mass estimated by waist circumference-to-height ratio predicts the risk of liver damage better than body mass index (BMI) estimated obesity, a new study shows.

11 Jun 2025

Rising liver disease cases demand immediate attention

During the first meeting of the Global Think-tank on Steatotic Liver Disease, supported by the Barcelona Institute for Global Health (ISGlobal) and held in the Palau Macaya of Barcelona on 5–6 June, more than 100 international experts issued a stark warning: millions of people will continue to go unseen by healthcare systems unless early detection and person-centred care for liver disease are prioritized without delay.

6 Jun 2025