Cirrhosis News and Research

Latest Cirrhosis News and Research

Type 2 diabetes drug shows improvements for patients with progressive liver disease

The sodium glucose cotransporter 2 (SGLT-2) inhibitor drug dapagliflozin, widely used to treat type 2 diabetes, also shows improvements for patients with progressive liver disease, finds a clinical trial from China published by The BMJ today.

5 Jun 2025

Hormone FGF21 reverses fatty liver disease by signaling the brain

A pioneering research study published today in Cell Metabolism details how the hormone FGF21 (fibroblast growth factor 21) can reverse the effects of fatty liver disease in mice. The hormone works primarily by signaling the brain to improve liver function.

13 May 2025

Low income linked to higher risk of dying from liver cancer

The risk of dying from the most common form of primary liver cancer is about 30 percent higher for patients with low household income compared to those with middle or high household income, according to a study at the University of Gothenburg.

5 May 2025

Semaglutide clears liver inflammation and cuts fibrosis in MASH patients, trial shows

A phase 3 trial shows that once-weekly semaglutide significantly improves liver histology in patients with metabolic dysfunction-associated steatohepatitis (MASH). The interim results also reveal meaningful weight loss and improved cardiometabolic markers, with a favorable safety profile.

4 May 2025

Semaglutide shows promise in treating severe liver disease

Semaglutide effectively treats liver disease in two thirds of patients, new research has found.

30 Apr 2025

MASLD in children linked to increased mortality and chronic complications

Researchers from University of California San Diego have found that children diagnosed with metabolic dysfunction-associated steatotic liver disease (MASLD) are at significantly increased risk of premature death and serious long-term health complications.

28 Apr 2025

Researchers pioneer method to measure liver tissue stiffness without damage

Researchers in South Korea have developed an organoid disease model and non-destructive stiffness analysis technology for evaluating the efficacy of new drugs for fatty liver disease.

25 Apr 2025

England faces persistent rise in alcohol deaths

The persistent higher rate of alcohol deaths in England since the pandemic in 2020 is an "acute crisis" requiring urgent action from government, according to a new study led by researchers at UCL and the University of Sheffield.

10 Apr 2025

Gum disease linked to worsening liver health

There is growing recognition in medicine that what happens in one part of the body can ripple through others.

9 Apr 2025

Conversations on AFM: Exploring the nanomechanics of living cells

In this interview Prof. Dr. Kristina Kusche-Vihrog speaks about the nanomechanics of living cells and their implications for cardiovascular disease.

From Bruker BioAFM 27 Mar 2025

Glutamate key to unlocking liver regeneration after acute damage

The liver is a vital organ, crucial to digestion, metabolism and the elimination of toxins. It has a unique ability, regeneration, which allows it to replace liver cells damaged by the very toxins that these cells eliminate.

26 Mar 2025

Besifovir dipivoxil maleate offers comparable efficacy and improved safety for hepatitis B patients

Hepatitis B is a liver infection cause by the hepatitis B virus (HBV), and long-term hepatitis B infections that last longer than six months are considered "chronic".

24 Mar 2025

£2.2 million grant supports clinical trials for liver dialysis device

Clinical trials to continue the development of a liver dialysis device to treat those with life-threatening liver disease have been funded by a grant awarded to UCL, the Royal Free Hospital and Yaqrit.

21 Mar 2025

Review explores the underlying mechanisms of hepatocarcinogenesis post-HCV eradication

Hepatitis C virus (HCV) infection remains a major global health burden, affecting millions worldwide and contributing significantly to hepatocellular carcinoma (HCC) development.

20 Mar 2025

Researchers move closer to a functional cure for chronic hepatitis B

Hepatitis B virus infection remains one of the leading causes of liver disease, including cirrhosis and hepatocellular carcinoma.

17 Mar 2025

Impact of excessive alcohol consumption on digestive health

Excessive alcohol consumption is a significant public health concern, responsible for approximately 6% of all deaths and contributing to 5.1% of the global disease burden.

12 Mar 2025

Nwd1 gene linked to liver dysfunction in metabolic disease

Metabolic dysfunction-associated steatohepatitis (MASH) is a liver disease that progresses without symptoms and is associated with significant global public health concerns.

11 Mar 2025

Study reveals the role of transcription factors as therapeutic gateways in MAFLD

Metabolic dysfunction-associated fatty liver disease (MAFLD) has become a growing global health concern, affecting millions worldwide. This complex liver disorder ranges from simple steatosis to more severe forms, including metabolic dysfunction-associated steatohepatitis (MASH), which may progress to fibrosis, cirrhosis, and even liver cancer.

11 Mar 2025

Existing drug could prevent liver damage caused by ammonia build-up

High levels of ammonia kill liver cells by damaging the mitochondria that power the cells. But this can be prevented using an existing drug due to start clinical trials, finds a new study in mice led by researchers from UCL.

7 Mar 2025

Asah1 gene plays key role in preventing progression of nonalcoholic fatty liver disease

Investigators have found that the gene Asah1 plays a crucial protective role in preventing the progression of nonalcoholic fatty liver diseases (NAFLD) into more severe forms of liver disease by regulating hepatic lipid homeostasis and cellular maintenance processes.

6 Mar 2025