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New nanobody-liposome combo stops lung cancer growth and delivers targeted chemotherapy

Researchers engineered a nanobody-conjugated liposome (A5-LNP-DOX) that targets CD155 and delivers doxorubicin directly to lung adenocarcinoma cells, dramatically suppressing tumor growth in preclinical models. This approach not only inhibited cancer cell migration and invasion but also showed strong potential for safer, more precise lung cancer therapy.

14 Jul 2025

Nasal antibody spray shields mice from pollen-triggered allergies and asthma

Intranasal delivery of a monoclonal IgG1 antibody targeting mugwort pollen protected mice from allergic rhinitis and asthma symptoms, without lowering systemic IgE levels. This localized, non-invasive approach dampened Th2 inflammation and preserved healthy airway tissue in sensitized mice.

14 Jul 2025

Fruit fly study sheds light on how new genes become functional

Most genes are ancient and shared across species. But a small subset of genes are relative newcomers, spontaneously emerging from stretches of DNA that once encoded nothing at all.

14 Jul 2025

Scientists discover how two distinct genes guide regeneration of sensory cells in zebrafish

While humans can regularly replace certain cells, like those in our blood and gut, we cannot naturally regrow most other parts of the body. For example, when the tiny sensory hair cells in our inner ears are damaged, the result is often permanent hearing loss, deafness, or balance problems.

14 Jul 2025

New imaging technique reveals mitochondrial activity inside live animals

In this study, researcher developed a new imaging approach that combines two powerful techniques to solve this problem. First, a special type of microscope called a two-photon microscope is used, which can look deep into live tissues with minimal damage.

14 Jul 2025

Sino Biological sets new industry standard with ProPure™ endotoxin-free proteins made in the USA

Sino Biological US, Inc. proudly unveils ProPure™, an industry-leading line of ultra-pure, endotoxin-free recombinant proteins, fully produced in the USA at its state-of-the-art Center for Bioprocessing (C4B) facility in Houston, Texas.

From Sino Biological Inc. 14 Jul 2025

New microchip tracks antibody-virus interactions from a single drop of blood

A new microchip invented by Scripps Research scientists can reveal how a person's antibodies interact with viruses-using just a drop of blood.

12 Jul 2025

New insights into how cells silence dangerous genomic elements

An international research team led by Freiburg biologists Dr. Wenjing Qi and Prof. Ralf Baumeister has discovered how the LINE1 retrotransposon exploits a cell protein to become active itself, as occurs in tumors.

12 Jul 2025

Uncovering the hidden architecture of the genome in three dimensions

In biology textbooks and beyond, the human genome and DNA therein typically are taught in only one dimension. While it can be helpful for learners to begin with the linear presentation of how stretches of DNA form genes, this oversimplification undersells the significance of the genome's 3D structure.

12 Jul 2025

Scientists identify key role of T-bet in flu memory B cells

At the surface, the immune response to a flu virus is simple. Some cells recognize the pathogen and send a signal to the immune system, and immune cells produce a potentially lifesaving antibody against the virus. Antigen in, antibody out.

11 Jul 2025

Explainable AI helps decode the substrate specificity of γ-secretase enzyme

Using artificial intelligence, researchers show how γ-secretase recognizes substrates - an important advance for fundamental and translational research.

11 Jul 2025

New discovery uncovers hidden drivers of DNA transcription errors

Every living cell must interpret its genetic code - a sequence of chemical letters that governs countless cellular functions.

11 Jul 2025

Researchers create over 400 types of nerve cells from stem cells

Nerve cells are not just nerve cells. Depending on how finely we distinguish, there are several hundred to several thousand different types of nerve cell in the human brain according to the latest calculations.

11 Jul 2025

Introducing the iQue® 5 HTS Platform: empowering scientists with unbeatable speed and flexibility for high throughput screening by cytometry

The life science group Sartorius launches the new iQue® 5 High-Throughput Screening (HTS) Cytometer, transforming workflows with next-level flexibility and comprehensive analysis at unbeatable speeds. Building on core iQue® strengths as the market leading solution for HTS applications, the iQue® 5 expands experimental range with up to 27 channels (25 color options) and flexible workflows in 96- and 384-well formats.

From Sartorius 11 Jul 2025

Mitochondria and peroxisomes work together to defend against cell damage

An international team led by researchers at The Hospital for Sick Children (SickKids), Princess Margaret Cancer Centre, Dalhousie University, the University of Exeter (UK) and the Medical University of Vienna (Austria) has uncovered a surprising way compartments within cells work together to defend themselves against oxidative stress, a finding that could shift how we understand age-associated conditions such as diabetes and neurodegenerative diseases.

10 Jul 2025

New type of algae offers breakthrough in cell cultivation

The time it takes to grow new skin for burns victims could be improved thanks to a new method of cell cultivation using algae, developed by University of Queensland researchers.

10 Jul 2025

Researchers uncover molecular switch controlling DNA packing in cell division

If measured from beginning to end, the DNA in our cells is too long to fit into the cell’s nucleus, explaining why it must be constantly folded and packaged.

10 Jul 2025

Breakthrough research uncovers multiple autism subtypes with unique traits

Researchers at Princeton University and the Simons Foundation have identified four clinically and biologically distinct subtypes of autism, marking a transformative step in understanding the condition's genetic underpinnings and potential for personalized care.

10 Jul 2025

Sticky cell coating boosts liver repair without the need for transplants

A new process could help to treat liver disease without needing an organ transplant, a new study reveals.

10 Jul 2025

Genetic insights reveal new targets for treating extracranial arteriovenous malformations

Our genes underlie all aspects of life, from our looks to how our cells behave. This includes diseases, as genetic changes can underlie the development and progression of certain health problems.

10 Jul 2025