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New strategy enhances immunotherapy effectiveness against glioblastoma by utilizing gut microbes

Advanced treatments, known as immunotherapies that activate T cells—our body's immune cells—to eliminate cancer cells, have shown limited efficacy as standalone therapies for glioblastoma, the most lethal form of brain tumor.

2 Jul 2025

Fidelio Capital partners with Alphalyse to accelerate the global roll-out of LC-MS host cell protein analytics

Alphalyse, a fast-growing Danish specialist contract research organization (CRO) that has developed GMP‑validated liquid‑chromatography mass‑spectrometry (LC‑MS) assays for host‑cell‑protein (HCP) impurity testing in biologic drugs, today announces that Fidelio Capital has acquired a majority stake in the company.

From Alphalyse A/S 2 Jul 2025

Single-cell transcriptomes of immune cells offer insight into juvenile idiopathic arthritis

Juvenile idiopathic arthritis (JIA), a type of arthritis commonly occurring in children, is a chronic, inflammatory condition that affects the joints, causing pain, swelling, stiffness, and limiting the range of motion.

2 Jul 2025

Shift Bioscience proposes improved ranking system for virtual cell models to accelerate gene target discovery

Shift Bioscience (Shift), a biotechnology company uncovering the biology of cell rejuvenation to develop new therapies for age driven diseases, today announced the results of a new study detailing an improved approach to ranking virtual cell models for gene discovery.

1 Jul 2025

Rarely studied RNA linked to triple-negative breast cancer

Breast cancer is one of the most common cancers among women in the United States. Thanks to decades of fundamental research, it's also one of the most curable.

1 Jul 2025

Improving RNA drug delivery through intracellular traffic control

A recent study involving researchers from the University of Basel reveals that slowing down the intracellular transport of RNA-based drugs can significantly enhance their effectiveness.

1 Jul 2025

Study uncovers how inflammation in brain blood vessels exacerbates damage in vascular dementia

A new study from UCLA Health has uncovered how inflammation in brain blood vessels exacerbates damage in vascular dementia and demonstrated that targeting this process with a repurposed drug can promote brain repair and functional recovery in mice.

1 Jul 2025

Researchers link genetic ancestry to severity of dengue fever

For the first time, the extreme variability in dengue fever has been linked to a biological mechanism, potentially opening doors to new treatments and vaccines for the most common mosquito-borne disease worldwide.

30 Jun 2025

Cannabis smoking changes your DNA, leaving epigenetic scars

Long-term, persistent weekly or more frequent cannabis smoking leaves a distinct and partially reversible epigenetic footprint on blood DNA. These methylation changes strongly overlap with those from tobacco and may serve as biomarkers of smoke exposure.

30 Jun 2025

Can a global vault save the world’s threatened microbiomes?

Researchers warn that accelerating human-driven loss of microbial diversity threatens both planetary and human health. The Microbiota Vault Initiative offers a global, equitable framework to safeguard critical microbiomes for future generations.

30 Jun 2025

New tool reveals hidden water patterns in protein structures

Every protein in the body is encased in a water shell that directs protein structure, provides vital stability and steers function.

30 Jun 2025

Ancient DNA sheds light on the origins of leprosy in the Americas

Hansen's Disease, more commonly known as leprosy, is a chronic disease that can lead to physical impairment. Today it exists in over 100 countries, and while the infection is treatable, access to treatment varies widely with socioeconomic conditions.

30 Jun 2025

New yeast model sheds light on proteasome and mitochondrial interaction

A study by the Center for Redox Processes in Biomedicine (Redoxoma) led by Marilene Demasi from the Butantan Institute (São Paulo, Brazil) presents a valuable new experimental model for investigating the interaction between the proteasome and mitochondrial function.

30 Jun 2025

Ionophore use in farming drives global spread of antibiotic resistance genes, study finds

Researchers identified the widespread presence of the ionophore resistance genes narA and narB in over 2,400 bacterial isolates across 51 countries. These genes are often genetically linked to resistance against critically important human antibiotics, raising concerns over agricultural practices and global antimicrobial resistance.

30 Jun 2025

How 50,000 years of ancestry shaped India’s unique disease patterns

Scientists sequenced the genomes of 2,762 individuals across India, revealing the country’s unique ancestral makeup and a wealth of previously undocumented disease-related gene variants. The study highlights how ancient migrations, founder effects, and endogamy have shaped both diversity and disease risk in India.

29 Jun 2025

Discovery of a genetic dimmer switch controlling embryonic development

A team of scientists at the MRC Laboratory of Medical Sciences (LMS) has uncovered a previously unknown mechanism that controls how genes are switched ‘on’ and ‘off’ during embryonic development.

27 Jun 2025

Expanding the genetic code in mammalian cells using pseudouridine modified codons

To overcome the inherent challenge of translation termination interference caused by stop codon reprogramming in mammalian cells, researchers from Peking University led by Chen Peng from College of Chemistry and Molecular Engineering and Yi Chengqi from School of Life Sciences have developed a novel codon expansion strategy that enables precise incorporation of noncanonical amino acids (ncAAs) without perturbing natural genetic codes.

27 Jun 2025

Global effort enters an active growth phase to preserve the Earth's microbial heritage

A global effort to create a "microbial Noah's Ark" to preserve the world's diverse collection of healthy microbes before they disappear is now entering an active growth phase.

27 Jun 2025

Proteome imbalance from aneuploidy linked to mitochondrial dysfunction

It has been known for several years that abnormal chromosome numbers lead to protein imbalances in the affected cells. Researchers at RPTU have now investigated the detailed effects of such imbalances.

27 Jun 2025

Investigating the role of ultra-processed foods in the inheritance of autism and ADHD

In a recent publication released by PubMed, American scientist Dr. Renee Dufault at the Food Ingredient and Health Research Institute, provides a peer-reviewed protocol for determining the role ultra-processed foods play in prenatal heavy metal exposures and changes in the expression of the zinc dependent MT-1 (metallothionein) gene that impact child neurodevelopment.

27 Jun 2025

Life Science News

New strategy enhances immunotherapy effectiveness against glioblastoma by utilizing gut microbes

Fidelio Capital partners with Alphalyse to accelerate the global roll-out of LC-MS host cell protein analytics

Single-cell transcriptomes of immune cells offer insight into juvenile idiopathic arthritis

Shift Bioscience proposes improved ranking system for virtual cell models to accelerate gene target discovery

Rarely studied RNA linked to triple-negative breast cancer

Improving RNA drug delivery through intracellular traffic control

Study uncovers how inflammation in brain blood vessels exacerbates damage in vascular dementia

Researchers link genetic ancestry to severity of dengue fever

Cannabis smoking changes your DNA, leaving epigenetic scars

Can a global vault save the world’s threatened microbiomes?

New tool reveals hidden water patterns in protein structures

Ancient DNA sheds light on the origins of leprosy in the Americas

New yeast model sheds light on proteasome and mitochondrial interaction

Ionophore use in farming drives global spread of antibiotic resistance genes, study finds

How 50,000 years of ancestry shaped India’s unique disease patterns

Discovery of a genetic dimmer switch controlling embryonic development

Expanding the genetic code in mammalian cells using pseudouridine modified codons

Global effort enters an active growth phase to preserve the Earth's microbial heritage

Proteome imbalance from aneuploidy linked to mitochondrial dysfunction

Investigating the role of ultra-processed foods in the inheritance of autism and ADHD

Unlocking drug amorphization: Continuous, solvent-free twin screw granulation

How can super-resolution technology help study neurotransmission?

The Proteoform Puzzle: Unlocking the Next Frontier

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